Intergenerational epigenetic programming of metabolic defects in a mouse model of undernutrition’

by Dr Anne Ferguson-Smith (University of Cambridge, UK)

Monday 8 Oct 2012, 14:00 → 15:00 Asia/Kolkata

AG-80 (Colaba Campus)

Using a mouse model of maternal caloric restriction during pregnancy affecting the metabolic physiology of two generations including paternal transmission of obesity and diabetes in the second generation, we will explore two questions: (i) Are imprinted genes more or less susceptible to environmental compromise and hence may be ‘developmental programming genes’ and (ii) Is the paternal experience of in utero undernutrition, resulting in metabolic defects in his offspring, an epigenetically inherited memory transmitted via his sperm methylome?