Nod-Like Receptors in Pathogen Recognition and Host Defense

by Dr Paras Anand (Department of Immunology, St Jude Children’s Research Hospital, TN, USA)

Thursday 21 Feb 2013, 16:00 → 17:00 Asia/Kolkata

B-333 (Colaba Campus)

Innate immune system relies on cytosolic Nod-like receptors (NLRs) to offer protection against microbial invasion by activating NF- and inflammasome signaling. Additionally, extracellular recognition of pathogens by Toll-like receptors (TLRs) promotes these functions by triggering robust pro-inflammatory responses. Yet, how these distinct innate pathways cross-talk to maintain immune homeostasis is not completely understood. Furthermore, which innate immune mechanisms eventually facilitate pathogen degradation is still unclear. Data from our recent studies highlighting the significance of NLRs in innate immunity, immune homeostasis and pathogen elimination will be discussed.