Elastic Network Model in describing equilibrium properties of proteins

by Dr Ranja Sarkar (Dept. of Chemical Sciences, TIFR, Mumbai 400005)

Monday 28 Apr 2014, 16:00 → 17:00 Asia/Kolkata

AG-69 (Colaba Campus)

In this talk, I will describe why elastic network model (ENM) is a faster alternative to standard molecular dynamics (MD) simulations in understanding the dynamics of proteins under equilibrium conditions. I will discuss the approaches taken for optimal parametrization of the model and how the parameters are used to study intrinsic flexibility of proteins. I will also talk about some future applications of ENM in studying specific functional motions of proteins.