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SUMMARY:Design of efficacious vaccines against respiratory viruses
DTSTART:20261007T103000Z
DTEND:20261007T123000Z
DTSTAMP:20261023T210600Z
UID:indico-event-9436@scitalks.tifr.res.in
DESCRIPTION:Speakers: Raghavan Varadarajan (MBU-IISc)\n\nViral acute lower
  respiratory infections directly or indirectly cause over a million deaths
  annually\, with a substantially higher toll in pandemic years. A large fr
 action of these deaths occur in infants and the elderly in low and middle 
 income countries. For most major respiratory viruses\, vaccines either do 
 not exist\, are unaffordable\, or have to be stored at ultralow temperatur
 es. Enhancing vaccine stability is important for both vaccine efficacy and
  deployment. There have been recent\, transformative advances in the area 
 of protein structure prediction. However\, even with state-of-the-art AI d
 riven approaches\, reliable prediction of stabilizing mutations for comple
 x\, viral surface proteins remains challenging.  We have developed genera
 l methodology to rapidly isolate stabilized protein variants\, including f
 or metastable viral surface proteins. Our efforts to apply this to design 
 and clinically test novel vaccines against important respiratory and other
  viruses will be discussed. An influenza vaccine formulation that we devel
 oped was shown to be safe in a human Australian Phase 1 trial\, and clinic
 al development in India is ongoing.\n\nhttps://scitalks.tifr.res.in/event/
 9436/
LOCATION:AG66
URL:https://scitalks.tifr.res.in/event/9436/
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